So, as I have demonstrated so far (I hope!), the main action of CCR2 in disease is causing the infiltration of immune cells (mainly monocytes) into tissues where it is not necessary or where the endogenous immune response has become amplified too much so that it results in diease. Consistent with this fact is CCR2’s involvement in other diseases, for which I have created a summary list below. This is by far an extensive list of where CCR2 manifests in disease but hopefully it will give you a feel for the vast array of diseases that this CC chemokine receptor contributes to and also the research that is done as a consequence.
For more information, Janeway’s Imunobiology textbook (8th Edition) is a good source for the mechanisms which are involved. Greater detail of the antagonist INCB3344 mentioned here can be found in an article published in he journal of Immunology which can be accessed by this link: http://www.jimmunol.org/content/175/8/5370.full.pdf+html
I hope you now have an appreciation for the scope of how important CCR2 research is. To highlight this (and for ease of reading), I will next go on to present a table summarising the CCR2 blocking drugs I have mentioned so far and some new ones that I have found along the way.
No comments:
Post a Comment