Some Solutions...

The failure of CCR2 blockade to come into the clinic inevitably leads to the assumption that something is going wrong with the transfer from animal models into humans and something must be done to rectify this if CCR2 is to become a successful therapy.

A major solution to this problem that  has been suggested and tested by several research groups is the idea of targeting multiple receptors, in particular CCR5 in conjunction with CCR2. And here is an explanation for why…

Targetting two or more receptors poses some problems when implementing the drug into the clinic, mostly concerning safety. Here are just a few examples of some of the issues raised.

This is just one of the ways of overcoming the current problems. I have barely touched the surface with regards to the extent of research into this topic and there are many hurdles yet to overcome.